Dear Aunt TUAW: Should I clean up my drive?

Dear Aunt TUAW,
I was looking at some apps that claim to help remove stored caches and temporary files. Are these apps a good way to clean up my Mac and remove temporary files?
Your loving nephew,
Chris

Dear Chris,
Auntie is super-paranoid about these third-party tools. When it comes to clearing data, Auntie generally sticks with Apple's built-in functionality and reasonably-regular reboots.
Auntie knows how easy it is to mess up system files and how hard it is to restore to a pre-mess state. They say Time Machine heals all wounds, but despite the name it doesn't actually get your time back.
Hugs,
Auntie T.
Got advice for Chris? Disagree with Auntie? Leave a note in the comments.
Source: http://tuaw.com/tag/aunttuaw
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